Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5268491 | Tetrahedron Letters | 2015 | 4 Pages |
Abstract
An efficient strategy for the synthesis of syn 1,3-diol has been developed, employing an imidazolidinone based chiral auxiliary via stereoselective and sequential double acetate aldol reactions. The syn 1,3-diol subunit was modified to obtain the C-7 carboxylic acid side chain and further subjected to reaction with a suitable 1,4-diketone under Paal-Knorr conditions to obtain atorvastatin lactone.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Sandeep Goyal, Bhautikkumar Patel, Ratnesh Sharma, Mangilal Chouhan, Kapil Kumar, Mukesh Gangar, Vipin A. Nair,