| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5268614 | Tetrahedron Letters | 2011 | 5 Pages |
Abstract
The one step synthesis of difluoromethylphosphonamidates from dialkylphosphonates is reported. The addition of lithiated amides onto dialkyl difluoromethylphosphonates afforded the corresponding phosphonamidates, as potential prodrug precursors. The remarkable high stability of these phosphonamidates in acidic medium was studied by 31P NMR.
Graphical abstractSynthesis of phosphonamidates was realized in one step from difluoromethylphosphonate dialkyl ester.Download full-size image
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Lucie Aliouane, Baptiste Rigaud, Emmanuel Pfund, Ludovic Jean, Pierre-Yves Renard, Thierry Lequeux,