Noncovalent catalysis of glucose-containing imidazolium salt in solvent-free one-pot synthesis of Ortho-aminocarbonitriles

A glucose-containing imidazolium salt β-1-imidazole-2,3,4,6-tetraacetyl-D-glucopyranosyl bromide was firstly used as efficient noncovalent organocatalyst to promote the solvent-free preparation of ortho-aminocarbonitriles via a four-component condensation of aromatic aldehyde, cyclohexanone, and 2 equiv of malononitrile at room temperature. Seven bonds were cleaved while four new bonds were formed and a six-membered ring was constructed in one-pot.

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