Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5268747 | Tetrahedron Letters | 2012 | 4 Pages |
Abstract
Organofluorine compounds are of high interest in modern drug discovery and material sciences. We herein report a new synthetic access to o-amino-2,2,2-trifluoroacetophenones starting from commercially available o-amino benzoic acids, which can easily be converted into the corresponding benzoxazinones. In a second step the trifluoromethylated ketone is formed via addition of Ruppert's reagent following acidic work up.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Nadine Allendörfer, Mazen Es-Sayed, Martin Nieger, Stefan Bräse,