| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5268754 | Tetrahedron Letters | 2012 | 4 Pages |
Abstract
An efficient route is described to an unusual exocyclic 4-β-d-ribofuranosyl-aminoimidazole nucleoside, related 4-N-benzylaminoimidazoles and imidazole analogues of precursors in the de novo biosynthesis of purines, via a regiospecific and stereoselective base-catalysed Dimroth-type rearrangement of 1-ribofuranosyl and 1-benzyl-5-aminoimidazoles. Use of a 15N labelled precursor showed the unequivocal endo- to exocyclic translocation of the nitrogen atom during the rearrangement.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
