| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5268814 | Tetrahedron Letters | 2010 | 4 Pages |
Abstract
The article describes a concise synthesis of a collection of 4,5-dihydro-1H-benzo[e][1,4]diazepines fused to a hydantoin ring, generated in a mere three steps. The protocol employs the Ugi-5-component CO2-mediated condensation, benzodiazepine formation promoted by acidic conditions and basic treatment to afford the fused hydantoin. Mechanistic caveats, dependent on the aldehydes of choice will be revealed and a facile oxidation of the final products to imidazolidenetriones is briefly discussed.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Steven Gunawan, Gary S. Nichol, Shashi Chappeta, Justin Dietrich, Christopher Hulme,