| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5268832 | Tetrahedron Letters | 2010 | 4 Pages |
Abstract
A two-step synthesis of 3-(2-chloropyrimidin-4-yl)imidazo[1,2-a]pyridines is presented. The late-stage elaboration of the imidazopyridine through a cyclocondensation allows a rapid access to a variety of substitution patterns. The intermediate enol ethers were obtained from inexpensive reagents in a ligand free Heck coupling. This methodology has been extended to the formation of pyrazolo[1,5-a]pyridines via a formal 1,3-dipolar cycloaddition.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
![A versatile route to 3-(pyrimidin-4-yl)-imidazo[1,2-a]pyridines and 3-(pyrimidin-4-yl)-pyrazolo[1,5-a]pyridines](/preview/png/5268832.png "First Page Preview: A versatile route to 3-(pyrimidin-4-yl)-imidazo[1,2-a]pyridines and 3-(pyrimidin-4-yl)-pyrazolo[1,5-a]pyridines")
Authors
Richard Ducray, Pascal Boutron, Myriam Didelot, Hervé Germain, Franck Lach, Maryannick Lamorlette, Antoine Legriffon, Mickael Maudet, Morgan Ménard, Georges Pasquet, Fabrice Renaud, Iain Simpson, Gail L. Young,