| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5268860 | Tetrahedron Letters | 2015 | 7 Pages |
Abstract
A range of propargylamines was synthesized via the metal-free decarboxylative coupling of alkynyl carboxylic acids with amines and paraformaldehyde in water, using a continuous flow reaction system. Aryl- and alkyl-substituted propiolic acids were found to react with secondary amines in the presence of paraformaldehyde, at 140 °C in water to give the desired propargylamines in good yield.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Bongkyun Jung, Kyungho Park, Kwang Ho Song, Sunwoo Lee,