| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5268958 | Tetrahedron Letters | 2014 | 4 Pages |
Abstract
1,2,3,5-Tetrasubstituted pyridinium amino acid isodesmosine is a crosslinking amino acid of elastin and is an attractive biomarker for the diagnosis of chronic obstructive pulmonary disease (COPD). Herein, we report an application of the Chichibabin pyridine synthesis to the total synthesis of isodesmosine. Specifically, the appropriate protected lysine and the corresponding aldehyde were reacted using Pr(OTf)3 in H2O/MeOH.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Takanori Sugimura, Akira Komatsu, Yohei Koseki, Toyonobu Usuki,