| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5268990 | Tetrahedron Letters | 2010 | 5 Pages |
Abstract
A highly regio-selective synthesis of novel glycospiropyrrolidines has been accomplished by 1,3-dipolar cycloaddition (1,3-DC) reaction. A unique dipolarophile derived from galactose has been reacted with azomethine ylide generated from 1,2-diketones and secondary aminoacids to give the corresponding spiro glycoheterocycles in good yields. The structures were assigned by 2D NMR spectra and the regio- and stereochemical outcome of the cycloadducts was established by a single crystal X-ray analysis.
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Authors
R. Prasanna, S. Purushothaman, R. Raghunathan,