| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5269013 | Tetrahedron Letters | 2015 | 4 Pages |
Abstract
A practical method for the Minisci reaction of electron-deficient pyrimidines with carboxylic acids is described. The one-step protocol allows for the alkylation of halo- and trifluoromethyl pyrimidines with a variety of readily available alkyl and (hetero)cycloalkyl carboxylic acids. These conditions permitted the facile synthesis of substituted pyrimidines, which are poised for further elaboration through divergent means.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Daniel G.M. Shore, Kimberly A. Wasik, Joseph P. Lyssikatos, Anthony A. Estrada,