Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5269125 | Tetrahedron Letters | 2011 | 5 Pages |
Abstract
A small family of readily available phosphoramidite ligands, including compounds with Pâ-stereocenters, has been prepared from phenyl-substituted 1,2-diols as simple and cheap starting materials. Using these ligands, up to 84% ee was achieved in Pd-catalyzed asymmetric allylic substitution. The influence of structural modules such as asymmetric atoms and steric demand on the enantioselectivity is discussed.
Related Topics
Physical Sciences and Engineering
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Organic Chemistry
Authors
Konstantin N. Gavrilov, Sergey V. Zheglov, Mariya N. Gavrilova, Ilya V. Chuchelkin, Nikolay N. Groshkin, Eugenie A. Rastorguev, Vadim A. Davankov,