| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5269132 | Tetrahedron Letters | 2011 | 4 Pages |
Abstract
The reactivity of N-(5-iodopyridin-2-yl)aminide in a copper-free Sonogashira cross-coupling process is reported. The reaction proceeds on using PdCl2(PPh3)2 and DABCO as the base under microwave irradiation in acetonitrile or water as solvents. The process can also be carried out by traditional heating in acetonitrile on using Pd(AcO)2/DABCO with Cs2CO3.
Graphical abstractThe Sonogashira copper-free cross-coupling reaction takes place efficiently on iodoaminide 6 employing DABCO as the base and Pd(OAc)2 or PdCl2(PPh3) as palladium catalyst under microwave irradiation in acetonitrile or water as solvents yielding mono-coupled products 8.Download full-size image
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Marta Córdoba, M. Luisa Izquierdo, Julio Alvarez-Builla,