| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5269209 | Tetrahedron Letters | 2010 | 4 Pages |
Abstract
A number of novel acid-sensitive Schiff bases derived from p-aminobenzyl alcohol and various benzaldehyde derivatives were synthesized and were subsequently shown to trigger benzyl elimination reactions. The kinetics of acid-catalyzed hydrolysis at pH 5.0 as well as stability at pH 7.4 were studied using fluorogenic model compounds. Two fluoro-substituted Schiff bases showed efficient hydrolysis at pH 5.0 combined with a long-term stability at pH 7.4 and are considered suitable candidates for the development of anticancer prodrugs.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ivonne A. Müller, Felix Kratz, Manfred Jung, André Warnecke,