Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5269333 | Tetrahedron Letters | 2011 | 4 Pages |
Abstract
Efficient Rh-catalyzed asymmetric 1,4-addition of arylboronic acids to ethyl-γ-phthalimidocrotonate by using bis-sulfoxide ligand affords γ-aminobutyric acid (GABA) derivatives with high enantioselectivities (90-96% ee) under mild conditions. Optically pure (S)-Baclofen and (S)-Rolipram have been prepared successfully through this synthetic route.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Fuzhong Han, Jun Chen, Xiangyang Zhang, Jibing Liu, Linfeng Cun, Jin Zhu, Jingen Deng, Jian Liao,