| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5269522 | Tetrahedron Letters | 2011 | 4 Pages |
Abstract
The first use of molecular sieves (MS) 5A as an acidic reagent is described. We observed the acidic property during a dehydration reaction of 2-methyl-4-phenyl-3-butyn-2-ol. The acidity was sufficient to introduce ethoxyethyl and methoxyisopropyl protecting groups into alcohols. Additionally, the employment of MS 5A improved the synthesis of 1,2,4-orthoacetyl-α-d-glucopyranose at the intramolecular transorthoesterification step. In the other step of the synthesis, MS 4A was also applied to demonstrate that the manipulation of MS simplified the total operations.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Noriaki Asakura, Tsukasa Hirokane, Hayato Hoshida, Hidetoshi Yamada,