Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5269536 | Tetrahedron Letters | 2011 | 4 Pages |
Abstract
A simple and useful method for the reduction of primary amides into the corresponding amines using a polymethylhydrosiloxane (PMHS)-Ti(OiPr)4 reducing system is described. Aromatic as well as aliphatic primary amides are reduced in high selectivity and excellent yields. The reduction could proceed via dehydration of the primary amide group into the corresponding nitrile which is then reduced into the corresponding primary amine.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Stéphane Laval, Wissam Dayoub, Leyla Pehlivan, Estelle Métay, Alain Favre-Réguillon, Dominique Delbrayelle, Gérard Mignani, Marc Lemaire,