Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5269555 | Tetrahedron Letters | 2011 | 5 Pages |
Abstract
A short and efficient synthesis for 5-substituted-4,6-dioxo-pyrrolo[2,3-d]pyrimidines has been developed by the cyclocondensation of α,α-dibromoaldehydes with 2,4-diamino-6-hydroxypyrimidine under mild basic conditions in good yields. Application of this protocol has been demonstrated in the synthesis of a metabolite of Pemetrexed disodium, a novel multi-targeted antifolate.
Related Topics
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Authors
N.M. Sekhar, Palle V.R. Acharyulu, Yerramilli Anjaneyulu,