| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5269572 | Tetrahedron Letters | 2011 | 4 Pages |
Abstract
A two-step procedure is described to access 3-alkoxycyclobutanones from chloroacetyl chloride utilizing a step-wise [2+2] ketene cycloaddition followed by catalytic hydrogenation to reduce the a-chlorine in a single reaction sequence. The resulting cyclobutanones can be readily converted into a variety of cis or trans-1,3-disubstituted aminocyclobutanols and cyclobutanediols.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Stacie Calad, Douglas Mans, Justin-Alexander Morin, Stacy O'Neill-Slawecki, Joseph Sisko,