| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5269613 | Tetrahedron Letters | 2014 | 4 Pages |
Abstract
A facile route toward substituted aryl diarylvinyl ethers 4 is developed from CuI-mediated cross-coupling reaction of substituted phenols 2 with diarylvinyl bromides 3 in the presence of various bidentate-based ligands in DMF. Skeleton 3 is prepared by Yan's bromomethylenation of diarylketones 1 with CHBr3-TiCl4-Mg in the co-solvent of DME and CH2Cl2. The synthetic route obtains moderate yields from the one-step operation and the key structure of 4k is confirmed by X-ray crystallographic analysis. The CADD docking experiments of 4k have been included.
Keywords
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Meng-Yang Chang, Hang-Yi Tai, Chung-Yu Tsai, Yi-Jing Chuang, Ying-Ting Lin,