| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5269617 | Tetrahedron Letters | 2014 | 4 Pages |
Abstract
A new and efficient total synthesis has been developed to obtain plagiochin G (22), a macrocyclic bisbibenzyl, and four derivatives. The key 16-membered ring containing biphenyl ether and biaryl units was closed via an intramolecular SNAr reaction. All synthesized macrocyclic bisbibenzyls inhibited Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells and, thus, are potential cancer chemopreventive agents.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Rui-Juan Li, Yu Zhao, Harukuni Tokuda, Xiao-Ming Yang, Yue-Hu Wang, Qian Shi, Susan L. Morris-Natschke, Hong-Xiang Lou, Kuo-Hsiung Lee,