Article ID Journal Published Year Pages File Type
5269668 Tetrahedron Letters 2014 4 Pages PDF
Abstract

A new method has been developed for the preparation of α,β-unsaturated carboxylic acids and corresponding esters with (E)-stereoselectivity via the TiCl4-mediated olefination of aldehydes. The method, which uses readily available acetic acid or its alkyl esters as active methylene partners, is more flexible and complementary to conventional routes in the preparation of (E)-cinnamic acid derivatives.

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Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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