| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5269699 | Tetrahedron Letters | 2010 | 4 Pages |
Abstract
Kansuinone (1), a rearranged euphane triterpenoid containing a spiro [5,6] ring system, was isolated from the roots of Euphorbia kansui. Its structure and stereochemistry were elucidated on the basis of spectroscopic, CD, and computational methods. Kansuinone (1) exhibited inhibitory activity against human and mouse 11β-HSD1 (11β-hydroxysteroid dehydrogenase type 1), with IC50 values of 1.12 and 1.08 μM, respectively.
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Authors
Jie Guo, Hong-Ping He, Xin Fang, Ying-Tong Di, Shun-Lin Li, Zhen Zhang, Ying Leng, Hui-Ming Hua, Xiao-Jiang Hao,