| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5269714 | Tetrahedron Letters | 2010 | 4 Pages |
Abstract
Synthesis of novel orthogonally protected 1,3,4-thiadiazole and 1,3,4-oxadiazole tethered dipeptide mimetics is described. Both the heterocycles are prepared via a set of diacylhydrazines derived from amino acids. 1,3,4-Thiadiazoles are synthesized by dehydrosulfurization using Lawesson's reagent while 1,3,4-oxadiazoles are obtained by EDC mediated cyclodehydration.
Graphical abstractSynthesis of orthogonally protected 1,3,4-thiadiazole and 1,3,4-oxadiazole tethered dipeptide mimetics through a common intermediate, peptidyl diacylhydrazines is described. 1,3,4-Thiadiazoles are synthesized by dehydrosulfurization using Lawesson's reagent while 1,3,4-oxadiazoles are obtained by the EDC mediated cyclodehydration.Download full-size image
Related Topics
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Authors
G. Nagendra, Ravi S. Lamani, N. Narendra, Vommina V. Sureshbabu,