Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5269758 | Tetrahedron Letters | 2011 | 4 Pages |
Abstract
We report herein the first example of a SNAr reaction using TDAE-initiated carbanions in quinazoline series. The o-nitrobenzyl carbanion, formed by the action of TDAE on o-nitrobenzyl chloride, reacts with 4-chloro-2-trihalomethylquinazolines 4 and 5 via a SNAr mechanism. This enabled a new series of 4-benzyl-2-trihaloquinazoline derivatives to be synthesized in good yields under mild reaction conditions offering promising prospects for pharmacomodulation.
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Authors
Marc Since, Omar Khoumeri, Pierre Verhaeghe, Martine Maillard-Boyer, Thierry Terme, Patrice Vanelle,