| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5269763 | Tetrahedron Letters | 2011 | 4 Pages |
Abstract
The intramolecular crossed aldehyde-ketone benzoin condensation in the chalcone of o-phthalaldehyde (OPA) catalyzed by N-heterocyclic carbene (NHCs) generated in situ from readily available imidazolium and thiazolium salts is described. In this reaction, bicyclic α-hydroxyl ketones (naphthalenone type tertiary alcohol) were selectively produced in good yields (75-94%) in shorter reaction times (20 min) through nucleophilic addition of acyl anion generated by umpolung in OPA-chalcone (regio controlled).
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Authors
Shravankumar Kankala, Ravikrishna Edulla, Sarangapani Modem, Ravinder Vadde, Chandra Sekhar Vasam,