| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5269831 | Tetrahedron Letters | 2010 | 4 Pages |
Abstract
The total synthesis of a proposed 1,3,4-trisubstituted isoquinoline 5 with an unprecedented 6-6-5-5 tetracyclic ring system is described. One of the key steps is an intramolecular aldol reaction with a combination of a Lewis acid (TBDMSOTf) and a mild base (i-Pr2NEt) to construct the central cyclopentane ring.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Hanbiao Yang, Eric Sjogren,