Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5269902 | Tetrahedron Letters | 2010 | 4 Pages |
Abstract
NiCl2 was found to be a highly efficient and effective catalyst for the one-pot three-component (A3) coupling of aldehydes, amines, and alkynes to produce propargylamines in nearly quantitative yields. Structurally divergent aldehydes, amines, and alkynes were converted into the corresponding propargylamines. No co-catalyst or activator is needed and water is the only byproduct of this novel protocol.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Subhasis Samai, Ganesh Chandra Nandi, M.S. Singh,