| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5269998 | Tetrahedron Letters | 2010 | 4 Pages |
Abstract
The first total synthesis of (+)-crassalactone B (2) and a new syntheses of (+)-crassalactone C (3) has been achieved starting from d-glucose. The natural products 2 and 3 can be selectively accessed by changing the conditions for TBDPS cleavage in the final intermediate 16. The synthesized natural products were evaluated for their cytotoxic activity against a panel of human tumour cell lines.
Graphical abstractCrassalactones B and C can be selectively accessed by changing the conditions for TBDPS cleavage in the final intermediate derived from d-glucose.Download full-size image
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Velimir Popsavin, Goran BenedekoviÄ, Mirjana Popsavin, Vesna KojiÄ, Gordana BogdanoviÄ,