Towards the synthesis of prevezol C: total enantioselective synthesis of (−)-2-epi-prevezol C

(−)-2-epi-Prevezol C was readily accessed from the chirons (−)- and (+)-limonene oxide in a total of nine steps and in 24% yield. This efficient enantioselective synthesis of this complex product utilises a highly stereoconvergent, substrate-controlled allylic alkylation strategy to assemble rapidly the unprecedented diterpene core.

Graphical abstract(−)-2-epi-Prevezol C was readily accessed from the chirons (−)- and (+)-limonene oxide in a total of nine steps and in 24% yield.Figure optionsDownload full-size imageDownload as PowerPoint slide