| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5270112 | Tetrahedron Letters | 2010 | 4 Pages |
Abstract
A novel synthesis of 2-trifluoromethyl-6-difluoromethylpyridine-3,5-dicarboxylates by three-component reaction of ethyl trifluoroacetoacetate, aldehydes, and ammonium acetate in the presence of K2CO3 under solvent-free conditions via sequential Hantzsch reaction/dehydration/dehydrofluorination in a one-pot process was described.
Graphical abstractA novel synthesis of 2-trifluoromethyl-6-difluoromethylpyridine-3,5-dicarboxylates via K2CO3-assisted one-pot sequential Hantzsch reaction/dehydration/dehydrofluorination under solvent-free conditions was described.Download full-size image
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Li Shen, Song Cao, Jingjing Wu, Hui Li, Jian Zhang, Mingxi Wu, Xuhong Qian,