Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5270160 | Tetrahedron Letters | 2010 | 4 Pages |
Abstract
Secondary phosphines, elemental selenium, and the natural alkaloids, lupinine and anabasine, interact in a three-component-type reaction under mild conditions (70 °C, 1-1.5 h, EtOH) without the formation of any by-products to give diselenophosphinates of the above-mentioned alkaloids (in almost quantitative yields) with the retention of their intrinsic optical activity. Thus, the developed synthesis represents an atom-economic route to new selenophosphorus derivatives of alkaloids.
Related Topics
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Authors
Nina K. Gusarova, Alexander V. Artem'ev, Svetlana F. Malysheva, Sergei V. Fedorov, Olga N. Kazheva, Grigorii G. Alexandrov, Oleg A. Dyachenko, Boris A. Trofimov,