Second-generation total synthesis of (−)-diversifolin

A second-generation total synthesis of (−)-diversifolin has been achieved by a more straightforward strategy, involving a highly stereochemistry-dependent 10-membered ring-closing metathesis and a stereoselective dihydroxylation/lactone transposition sequence. Compared to our previous synthesis, the present synthesis is improved in the yield of the key intermediate 2 (20% in 12 steps from diol 8).

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