Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5270239 | Tetrahedron Letters | 2010 | 4 Pages |
Abstract
The chiral N,Nâ²-dioxide-Yb(OTf)3 complex-catalyzed enantioselective aza-Diels-Alder reaction of Brassard's diene with aldimines has been developed, giving the corresponding α,β-unsaturated δ-lactam derivatives in moderate yields with good enantioselectivities (up to 81% ee and up to 99% ee by single recrystallization) under mild conditions. Isolation of the reaction intermediate indicates that this asymmetric aza-Diels-Alder reaction proceeds through a stepwise Mannich-type pathway.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Zhenling Chen, Lili Lin, Donghui Chen, Jiangting Li, Xiaohua Liu, Xiaoming Feng,