Article ID Journal Published Year Pages File Type
5270292 Tetrahedron Letters 2014 4 Pages PDF
Abstract

A rhodium-catalyzed oxidative C2-alkenylation of indoles containing a N-(p-tolyl)carboxamide group with substituted alkynes via CC bond formation and subsequent CN bond cleavage has been described. This protocol represents direct access to C2-alkenylated free (NH)-indoles, which are important building blocks in the synthesis of natural and pharmacological compounds.

Graphical abstractDownload full-size image

Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
Authors
, , , , , , , , , ,