Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5270297 | Tetrahedron Letters | 2014 | 4 Pages |
Abstract
Pentacyclic triterpenoids α- and β-amyrin possess a wide range of biological and pharmacological activities. High structural similarity between these two structural isomers makes their chromatographic separation an ineffective and tedious choice. In this study, Candida rugosa lipase catalyzed separation protocol for the isolation of individual isomers has been developed. In the presence of vinyl acetate as the acyl donor, Candida rugosa lipase carried out acetylation of β-amyrin more efficiently as compared to α-amyrin leading to a kinetic separation. The conditions of transesterification reaction were optimized systematically, which was utilized to separate α- and β-amyrin from a mixture obtained from the latex of Plumeria obtusa.
Related Topics
Physical Sciences and Engineering
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Organic Chemistry
Authors
Saikat Haldar, Balaji S. Kale, Dipesh D. Jadhav, Hirekodathakallu V. Thulasiram,