Article ID Journal Published Year Pages File Type
5270388 Tetrahedron Letters 2013 5 Pages PDF
Abstract

A highly efficient organocatalytic approach has been developed for the diastereoselective epoxidation of (E)-3-ylidene-indolin-2-one derivatives using readily available natural product quinine and urea-hydrogen peroxide (UHP) in DCM at 10 °C to afford trans spiro-epoxyoxindoles which were further utilized to obtain β-hydroxy-α-amino esters by water mediated regioselective ring opening from the less hindered end with aniline derivatives, under sonication.

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Physical Sciences and Engineering Chemistry Organic Chemistry
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