Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5270388 | Tetrahedron Letters | 2013 | 5 Pages |
Abstract
A highly efficient organocatalytic approach has been developed for the diastereoselective epoxidation of (E)-3-ylidene-indolin-2-one derivatives using readily available natural product quinine and urea-hydrogen peroxide (UHP) in DCM at 10 °C to afford trans spiro-epoxyoxindoles which were further utilized to obtain β-hydroxy-α-amino esters by water mediated regioselective ring opening from the less hindered end with aniline derivatives, under sonication.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Mangilal Chouhan, Anang Pal, Ratnesh Sharma, Vipin A. Nair,