Synthesis of marchantin C, a novel microtubule inhibitor from liverworts

Recently, remarkable microtubule inhibitor and anti-tumor activities of the bisbibenzyl marchantin C-isolated from liverworts like Marchantia polymorpha since 1983-were found. In this Letter we describe the first and efficient total synthesis of this subtype of bisbibenzylic compounds with two biarylether connections. The structure was confirmed by the spectroscopic data which were analyzed carefully to exclude any errors in arene connection and substitution pattern.

Graphical abstractMarchantin C, a natural product from liverworts was now found to be highly active. We present the first total synthesis of this macrocyclic (bis)biarylether compound.Download full-size image