| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5270442 | Tetrahedron Letters | 2011 | 4 Pages |
Abstract
A novel and efficient synthetic route to the anti-cancer natural product yomogin has been developed using a Telescoped Intramolecular Michael-Olefination (TIMO) sequence as the key step. Two variants of the TIMO sequence have been used successfully: a two-step acylation approach using diethyl phosphonoacetic acid and a base-free variant using triphenylphosphoranylideneketene (Bestmann's ylide). The natural product, 3-oxodiplophyllin, was also prepared en route to yomogin.
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Authors
Russell R.A. Kitson, Graeme D. McAllister, Richard J.K. Taylor,