| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5270694 | Tetrahedron Letters | 2014 | 4 Pages |
Abstract
A stereoselective total synthesis of 13-membered macrocycle PF1163A, an antifungal agent, has been accomplished for the first time starting from d-xylose. This approach involves a diastereoselective allylation of lactal ether,3a reductive ring opening of tetrahydrofuran ring,3b asymmetric methylation reaction, Yamaguchi esterification, and ring closing metathesis as key steps.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Harish Kumar, A. Srinivas Reddy, B.V. Subba Reddy,