Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5270699 | Tetrahedron Letters | 2014 | 4 Pages |
Abstract
â¢Mild reaction conditions for the preparation of substituted semicarbazides.â¢The preparation method applicable to structurally diverse semicarbazides.â¢Building semicarbazide library from amines, hydrazines, and phenyl chloroformate.
A simple synthetic procedure for the conversion of amines and hydrazines into substituted semicarbazides was developed. The initial condensation between the desired amine and phenyl chloroformate into phenyl carbamate is followed by the addition of hydrazine under basic conditions. The reaction is tolerable to a variety of functional groups, with mild conditions and high percent yields.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Rebecca Hron, Branko S. Jursic,