Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5270702 | Tetrahedron Letters | 2014 | 5 Pages |
Abstract
The palladium-catalyzed cyclization-allylation reaction of ortho-azido propynylbenzenes 1 and allyl methyl carbonate 2d gives the corresponding allylated quinolines in moderate to good yields. The reaction of 1-azido-2-(2-propynyl)benzene 1a proceeds smoothly with 10 mol % Pd(PPh3)4 and 5 equiv K3PO4 or NaOAc in DMF at 100 °C to afford 3,4-diallylquinoline 3a in 69% yield in the case of R2 = H and 3-allylquinoline 4 in 67% yield in the case of R2 â  H.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jiang Luo, Zhibao Huo, Jun Fu, Fangming Jin, Yoshinori Yamamoto,