Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5270707 | Tetrahedron Letters | 2014 | 4 Pages |
We describe concise and efficient synthesis of 2â²-deoxyadenosine-3â²-O-triphosphate (2â²-d-3â²-ATP) and 2â²-deoxycytidine-3â²-O-triphosphate (2â²-d-3â²-CTP) which are well known for their various biological applications. One-pot synthetic methodology was used to convert N6-Benzoyl-5â²-O-levulinoyl-2â²-deoxyadenosine into N6-Benzoyl-5â²-O-levulinoyl-2â²-deoxyadenosine-3â²-O-triphosphate in 72% yield. One-step concurrent deprotection of N6-Benzoyl and 5â²-O-levulinoyl groups using concentrated aqueous ammonia resulted in 2â²-d-3â²-ATP in 75% yield. The same synthetic strategy was successfully employed to convert N4-Benzoyl-5â²-O-levulinoyl-2â²-deoxycytidine into 2â²-d-3â²-CTP in 66% yield.
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