| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5270723 | Tetrahedron Letters | 2014 | 4 Pages |
Abstract
Targeted inactivation of the mpp7 gene in the Monascus azaphilone pigment (MAzP) biosynthetic gene cluster resulted in the accumulation of monasfluol A (7) and B (8), of which the latter was a novel compound, and the abolition of the main MAzPs. It is thus proposed that 7 and 8 are the products of non-enzymatic Knoevenagel condensation followed by a reduction and that Mpp7 assists in regioselective Knoevenagel aldol condensation during MAzP biosynthesis.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Bijinu Balakrishnan, Chien-Chi Chen, Tzu-Ming Pan, Hyung-Jin Kwon,