Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5270748 | Tetrahedron Letters | 2009 | 4 Pages |
Abstract
Iodine is shown to be an efficient catalyst for the Friedel-Crafts alkylation of arenes with a wide variety of aldehydes in toluene under 'open-flask' and mild conditions. In the presence of 10 mol % of iodine, the reaction of arenes with aromatic aldehydes gives the corresponding triarylmethane derivatives (TRAMs), regioselectively, in good to excellent yields. On the other hand, a series of diarylalkane derivatives is synthesized smoothly by the reaction with aliphatic aldehydes.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jaray Jaratjaroonphong, Supaporn Sathalalai, Prapapan Techasauvapak, Vichai Reutrakul,