| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5270758 | Tetrahedron Letters | 2009 | 5 Pages |
A new and facile method has been developed for the one-step synthesis of 5-chloro-imidazo[1,5-a]quinazoline by cyclization of N-acylanthranilic acid A with 2-amino acetamide B1 or 2-amino-acetonitrile B2 in the presence of POCl3 under microwave irradiation. 5-chloro-imidazo[1,5-a]quinazolines can be further functionalized by displacement of 5-Cl group.
Graphical abstractA new and facile method has been developed for the one-step synthesis of 5-chloro-imidazo[1,5-a]quinazoline by cyclization of N-acylanthranilic acid A with 2-amino acetamide B1 or 2-amino-acetonitrile B2 in the presence of POCl3 under microwave irradiation. 5-chloro-imidazo[1,5-a]quinazolines can be further functionalized by displacement of 5-Cl group.Figure optionsDownload full-size imageDownload as PowerPoint slide
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