Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5270835 | Tetrahedron Letters | 2010 | 4 Pages |
Abstract
A practical and efficient two reaction sequence one-pot process for the synthesis of Z-α-benzoylamino-acrylic acid methyl esters was developed. The process involves a potassium phosphate-catalyzed Erlenmeyer reaction of aromatic aldehydes with hippuric acid followed by an oxazolone ring-opening methanolysis. This process afforded a good overall yield and an excellent product quality via a simple workup.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Thomas Cleary, Jodie Brice, Nicole Kennedy, Flavio Chavez,