Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5270856 | Tetrahedron Letters | 2010 | 5 Pages |
Abstract
Tryptamine, aryl aldehyde, and benzyl chloride undergo smooth coupling using well-ordered mesoporous AlSBA-15 catalyst with hexagonal porous structure in acetonitrile at 80 °C to furnish tetrahydrocarbolines in good yields with a high selectivity. This reaction also proceeds with homoveratrylamine to give the corresponding tetrahydroisoquinolines. A variety of aryl and heteroaryl aldehydes have also been used for producing tetrahydrocarbolines in high yields. This AlSBA-15-promoted Pictet-Spengler reaction provides a mild alternative to the traditional Brönsted or Lewis acids typically employed for the preparation of tetrahydrocarbolines and tetrahydroisoquinolines.
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Physical Sciences and Engineering
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Authors
Ajayan Vinu, Pranjal Kalita, Leila Samie, Murugulla Adharvana Chari, Ravindra Pal, B.V. Subba Reddy,