A rapid and efficient synthesis of a new pyrrolobenzodiazocines via an intramolecular Friedel–Crafts reaction

New pyrrolobenzodiazocines 3 have been prepared by an intramolecular Friedel–Crafts process from pyrrolobenzoacrylamides 2. The cyclisation process involving a 1,4-intramolecular addition of a pyrrole onto acrylamide led to the formation of an eight-membered ring.

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