Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5271004 | Tetrahedron Letters | 2013 | 6 Pages |
Abstract
A simple, efficient, and new method is developed for the synthesis of α-aminophosphonates via a three-component, catalyst-free decarboxylative coupling of amino acids with aldehydes and H-dialkyl phosphite. Treatment of amino acids with aldehydes and diethyl phosphite in the absence of catalyst, base, and ligand give α-aminophosphonates in moderate to good yields. This method is simple, rapid, and high-yielding.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Babak Kaboudin, Leila Karami, Jun-ya Kato, Hiroshi Aoyama, Tsutomu Yokomatsu,